We are used to the fact that when it comes to microorganisms, we mean mainly some harmful bacteria. However, beneficial microorganisms are widespread in nature.   One of these are lactobacilli, which form lactic acid, which has a positive effect on the intestine, and some types of bacilli, secreting digestive enzymes and help in this way to effectively digest food. Extremely important for the digestion of ruminants are rumen microorganisms, which help to destroy the fiber and turn it into nutrients that are absorbed in the following parts of the gastrointestinal tract. Most beneficial bacteria compete with opportunistic bacteria through so-called “competitive repression.” Kolonizuyuchis on the surface of the intestinal epithelium, beneficial bacteria capture free space and do not allow harmful microorganisms there. In scientific terminology, these beneficial bacteria are called probiotic, and the drugs produced on their basis-probiotics. Probiotics should not be confused with prebiotics, which also exhibit antagonistic properties towards pathogenic and opportunistic microorganisms, but unlike probiotics, are not living microorganisms.

Probiotic and prebiotic drugs can be combined in many cases, achieving a synergistic effect. This is quite logical, especially since some types of prebiotics are products of the activity of probiotic bacteria. For example, the prebiotic lactic acid is formed by lactic acid bacteria, the prebiotic propionic acid is formed by propionic acid bacteria, and the like. Probiotic and prebiotic drugs have fundamental advantages over feed antibiotics, they do not accumulate in the body, do not cause the formation of resistant forms of bacteria. Such preparations can be used during the entire period of animal rearing, up to the slaughter, and the products obtained with the use of these preparations are environmentally friendly.

Probiotics and prebiotics are of great importance for the silage of feed and for the storage of feed raw materials. Beneficial bacteria and products of their secretion prevent the development of mold fungi, the accumulation of mycotoxins, which makes it possible to reduce the toxicity of feed, improve feed conversion and absorption of nutrients.

The industry of probiotics and prebiotics is widely developed in the world, including in the CIS countries. Ukrainian company Kronos agro produces a wide range of probiotic-prebiotic specialized drugs and drugs of complex action, developed by specialists of the company biocontact in cooperation with NPF “microbiological probiotics and preservatives” (St. Petersburg, Russia), and VF ” microbiotics “(Republic of Belarus).

Lactoflor (silage ferment) is a liquid biological preparation of pure culture of lactic acid bacteria Lactobacillus plantarum, strain GG 500/600, which contains at least 1 million columns of lactobacilli. In addition to lactobacilli, the drug also contains enzymes: xylanase, amylase, beta-glucanase.  Lactoflor increases the nutritional value of canned food, digestibility of dry matter and fiber, which contributes to the productivity of animals. The drug, which is attached to the green mass, causes a rapid growth of lactic acid bacteria that produce lactic acid, which acidifies the environment, suppresses the processes of decay, prevents the processes of butyric acid fermentation. Lactoflor changes the direction of fermentation processes to the optimal ratio of lactic and acetic acids (70% and 30%, respectively). The preparation contributes to the preservation of protein (more than 93%) and the overall nutritional value of silage. Enzymes contained in Lactoflora destroy plant polysaccharides, forming simple carbohydrates, which is a nutrient substrate for lactic acid bacteria. This gives rise to rapid propagation of the crop even with heavy silage herbs that contain low amounts of available carbohydrates. Consumption of the drug is 1 liter per 15 tons of green mass. In the upper layer of green mass is recommended to make a double dose of the drug, it protects the silo from rotting. Contraindications for the use of the drug does not have, myaso and milk from animals are used without restrictions. Shelf life of the drug 3 months, storage temperature from 4 to 25 Seconds. Packaging in plastic bottles or cans. The drug has all the necessary certificates and is successfully used in Belarus and Russia, registration certificate in Ukraine.

Imunobakterin-L. Liquid probiotic immunobiological preparation, contains a mixture of bacteria Bacillus subtilis and Bacillus licheniformis in an amount of 5×10 \ 9 colons per gram, and zinc chelate 0.5 g / kg. the Preparation strengthens the immune system and increases the safety of livestock. Improves intestinal microflora by bacterial colonization, shows antagonistic action to pathogenic and opportunistic bacteria, improves digestion and feed conversion. Imunobakterin is used for broilers, laying hens and parent livestock, turkeys, pigs and pigs at a dose of 1-2l per tonuvodi by vypaivaniya, and for calves at the rate of 10 g per calf per day with milk or with ztsm. Shelf life of the drug 12 months when stored at a temperature of 2 to 10 C or 6 months when stored at a temperature of 10 to 25C. Store the drug should be in a dark, dry room, avoiding direct sunlight. Packaging-plastic bottles or cans 0, 1 – 10 l. Registration posvidchennyav Ukraine BB-00280-02-10.

Imunobacterin-D is a drug of the same composition and action as liquid Imunobacterin, but in the form of a powder, which allows it to be used in the process of preparing feed, or introduced into premixes and bmvd. Dosage: 0, 2 -0, 4 kg per ton of finished feed for all types of animals, calves 5 g per day, dissolving the drug in milk or ztsm. Registration certificate in Ukraine BB 00279-02-10.

Vaginal suppositories Supozit Plus (registration certificate BB-00281-02-10). Suppository weighing 4, 7 g contains 5×10 \ 8 koloniyutvoryuyuchih units of probiotic bacteria Bacillus subtilis and Bacillus licheniformis and 4600 units of colistin sulfate and foaming components. The combination of probiotic bacteria with colistin ensures high efficiency of the drug. Supasit Plus is used for treatment and prevention of endometritis, mastitis and improve the efficiency of artificial insemination. You can use the drug in conjunction with antibiotics: colistin, penicillin, Amoxicillin, tetracycline. The drug should not be used in conjunction with tylosin, gentamicin, sulfonamides, enrofloxacin and doxycycline, to which the bacteria contained in the Suposite are sensitive.

Application method:

Cows-12 hours before insemination and 12 hours after mating one suppository. A few days before the expected calving, one suppository intravaginally once, after calving, after natural or forced release of the uterus from the placenta, two suppositories into the uterine cavity immediately and one after 10-12 hours. After the end of the course of antibiotic therapy to prevent dysbacteriosis, one suppository once a day for 3-5 days. Suppositories should be administered with the fingers as deeply as possible, in compliance with the rules of hygiene.
Pigs, cattle: similar to cows, but in half dose. To do this, the suppository must be broken into two equal parts (along the fault line).
Supasit packaged in blisters, the shelf life is two years.